Academic Education:

B.S., Pembroke College in Brown University
Ph.D., The Rockefeller University


Appointments:

Research Fellow, Department of Physiology, Harvard Medical School, Boston, Massachusetts (1971 - 1973)

Assistant Professor of Biology, Northeastern University (1973 – 1978)

Associate Professor of Biology, Northeastern University (1978 – 1984)

Sabbatical: Guest Worker, National Cancer Institute (1981)

Professor of Biology, Northeastern University (1984 – present)

Special Assignment to the Executive Vice President, Northeastern University (1987)

Sabbatical: Visiting Scholar, Department of Biochemistry, Harvard University (1988)

Sabbatical: Senior Scientist, Sealy Center for Molecular Science, University of Texas Medical Branch-Galveston, Laboratory of Dr. Samuel H. Wilson (1994 – 1995)

Sabbatical 9/01-12/01Professeur Invitee, Institut Gustav Roussy, Villejuif, France (2001)

Sabbatical 1/02-9/02 Guest Researcher, National Institute of Environmental Health Sciences, Laboratory of Structural Biology (2002)

Fulbright Research Scholar, Department of Zoology, Banaras Hindu University, Varanasi, India (2010)

Other Professional Activities:

EDITORIAL BOARDS
DNA Repair (2004-present)

MEMBERSHIPS
AAAS (1964 – present)
Sigma Xi (1965)
Lipid Club of New York (1967 – 1970)
American Society of Protozoologists (1967 – 2004)
New York Academy of Sciences (1911 – 1987)
American Society of Cell Biologists (1972 – present)
American Women in Science (1977 – present)
American Association of Immunologists (1980 – 1987)
NIH Alumni Association (1982 – 1987)
American Society for Biochemistry and Molecular Biology (1984 – present)
Society for Experimental Biology and Medicine (1986 – 1990)
Radiation Research Society (1998 – present)
American Chemical Society (2000-present)
American Physiological Society (2009)

NIH STUDY SECTION SERVICE
Radiation Study Section: 6/01
Ad Hoc Reviewer: 11/02; 6/03; 5/04; 10/04
NCI Manpower and Training Grants: 3/05

ADVISORY COMMITTEES
Reviewer for the National Science Foundation, National Institutes of Health, National Research Council's Graduate Fellowship Evaluation Panel in Biochemistry and Biophysics, USDA Human Nutrition Center on Aging at Tufts University, Veteran's Administration, Alberta Heritage Foundation, John Wiley & Sons, Publishers, Journal of Immunology, Journal of Medicinal Chemistry, Journal of Cell Biology, Canadian Journal of Biochemistry, Journal of Cellular Physiology, Biochemical Pharmacology, Experimental Cell Research, Biochimica Biophysica
Acta, Biochemistry (Washington), United States Information Agency, Department of Defense, Sealy Center for Molecular Science, Galveston TX, Biotechniques, Cellular and Molecular Life Sciences, Nucleic Acids Research, FEMS Letters, The Petroleum Research Fund and Journal of Molecular Biology

Research Interests:

The Strauss lab studies the biochemistry and cell biology of DNA repair, focusing particularly on the enzyme AP endonuclease.


Teaching Activities:

Teaching responsibilities have revolved primarily around biochemistry and cell biology at the introductory, intermediate and graduate levels.

Selected Publications:

Pei, D.S., Yang, X.J., Liu, W., Guikema, J.E.J., Schrader, C.E. and Strauss, P.R. 2010 A DNA repair protein (AP endonuclease 1) regulates DNA polymerase ß through Creb1 Nucleic Acids Res. doi:10.1093/nar/gkq1142.

Kanazhevskaya, L.U., Koval, V.K., Zharkov, D., Strauss, P.R. and Fedorova, O.S.
Conformational transitions in human AP endonuclease 1 and its active site mutant during abasic site repair 2010 Biochemistry 49, 6451-6461.

Fortier, S.F., Yang, X.J., Wang, Y., Bennett, R.A. and Strauss, P.R. 2009 Base excision repair in developing zebrafish: functional evidence for polymerase switching and multiple AP endonucleases Biochemistry 48, 5396-5404.

Mundle, S.T., Delaney, J.C., Essigmann, J.M. and Strauss, P.R. 2009 Enzymatic mechanism of human apurinic/apyrimidinic endonuclease on a tetrahydrofuran-containing substrate Biochemistry 48, 19-26.

Abyzov, A., Uzun, A., Strauss, P.R., and Ilyin, V.A. 2008 An AP endonuclease 1-DNA polymerase ß complex: Theoretical prediction of interaction pLoS Computational Biology 4, e1000066.

Guikema, J.E., Linehan, E.K, Tsuchimoto, D., Nakabepppu, Y., Strauss, P.R., Stavnezer, J. and Schrader, C.E. 2007 APE-1 and APE-2 dependent DNA breaks in immunoglobulin class switch recombination J. Exp. Med. 204, 3017-3026. Erratum in: J. Exp. Med. 204, 3295, 2007.

Melo, L., Mundle, S., Fattal, M., O’Regan, N.O. and Strauss, P.R. 2007 Role of active site tyrosines in dynamic aspects of DNA binding by AP endonuclease DNA Repair 6, 374-382.

Wang, Y., Shupenko, C.C., Melo, L.F. and Strauss, P.R. 2006 A DNA repair protein involved in heart and blood development Molecular Cell Biology 26, 9083-9093.

Mundle, S.T., Fattal, M.H., Melo, L.F., Coriolan, J.D. and Strauss, P.R. 2004 Novel role of tyrosine in catalysis by human AP endonuclease 1 DNA Repair 3, 1447-1455.

Mckenzie, A.J. and Strauss, P.R. 2003 A quantitative method for measuring protein phosphorylation Analyt. Biochem. 313, 9-16.

Mckenzie, A.J. and Strauss, P.R. 2003 A quantitative method for measuring protein phosphorylation Analyt. Biochem. 313, 9-16.

Kolaczkowski, S.V., Perry, A., Mckenzie, A., Johnson, F., Budil, D.E. and Strauss, P.R. 2001 A spin-labeled abasic DNA substrate for AP endonuclease. Biochem. Biophys. Res. Commun.. 288, 722-726.

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