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M. Jade Zee
Assistant Academic Specialist
BNS Advisor
Ph.D.,
University of Oregon
Research
Areas:
Behavioral Neurobiology, Neuroendocrinology
Publications
Email: m.zee@neu.edu
Phone:
617.373.4861
Fax: 617.373.3724
Location:
112 A Mugar Life Sciences
Mail: NU/Biology
134 Mugar Life Sciences
360 Huntington Avenue
Boston, MA 02115
USA
Research
Description
The goal of my research is to understand the mechanisms and functional consequences of steroid hormones in the nervous system. Hormones have pervasive influences on behavior both in vertebrates and invertebrates and at the level of individual neurons and neural circuits. I have investigated the seasonal and sex-specific acoustic communication in teleost fishes as well as steroid-mediated programmed cell death in lepidopteran (moths) during insect metamorphosis. An accompanying research interest in central pattern generators, motoneurons involved in behaviors in the absence of sensory input, has developed from my work on the teleost hindbrain vocal pattern generator.
Kinch, G.L., Hoffman, K.L., Rodrigues, E.M., Zee, M.C. and Weeks, J.C. (2003) Steroid-triggered programmed cell death of a motoneuron is autophagic and involves structural alterations in mitochondria. J. Comp. Neurol. 457: 384-403.
Zee, M.C. and Weeks, J.C. (2001) Developmental change in the steroid hormone signal for cell-autonomous, segment-specific programmed cell death of a motoneuron. Dev. Biol. 235: 45-61.
Gruol, D.J., Vo, Q.D. and Zee, M.C. (1999) Profound differences in the transport of steroids by two mouse P-glycoproteins. Biochem. Pharmacol. 58(7): 1191-9.
Simerly, R.B., Zee, M.C., Pendleton, J.W., Lubahn, D.B. and Korach, K.S. (1997) Estrogen receptor-dependent sexual differentiation of dopaminergic neurons in the preoptic region of the mouse. Pro. Natl. Acad. Sci. 94: 14077-14082.
Gu, G., Rojo, A.A., Zee, M.C., Yu, J. and Simerly, R.B. (1996) Hormonal regulation of CREB phosphorylation in the anteroventral periventricular nucleus. J. Neurosci. 16(9): 3035-3044.
Simerly, R.B., Carr, A.M., Zee, M.C. and Lorang, D. (1996) Ovarian steroid regulation of estrogen and progesterone receptor messenger ribonucleic acid in the anteroventral periventricular nucleus of the rat. J. Neuroendo. 8: 45-56.
Gruol, D.J., Zee, M.C., Trotter, J. and Bourgeois, S. (1994) Reversal of multidrug resistance by RU 486. Cancer Res. 54: 3088-3091.
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